The life of the ranch hands is characterized by hard work, first and foremost, and also loneliness, isolation and powerlessness. Though most of the men work and bunk together, they are presented as existing in a situation where every man is on his own.
Loneliness is a recurrent theme in the novel. "Guys like us," George says, "that work on the ranches, are the loneliest guys in the world. They got no family. They don't belong noplace."
Candy and Crooks are the best examples of the ranch hands being isolated and lonesome. Candy has just one friend, an old dog. He also has only one hand, so he can no longer do much work on the ranch. Without the ability to work, Candy is powerless in ways that are literarl and figurative. He has no property, no family, and no real wealth.
This state of affairs characterizes all of the ranch hands. Only Lennie and George can be said to have a friend.
Crooks is forced to stay in his own room in the stable and is not allowed to mix freely with the other ranch hands. There is a definite, if invisible, line between Crooks and the other ranch hands drawn due to race.
Crooks' racial identity parallels the economic or financial identity of the ranch hands. They are separate from the big house, separate from Curley and Curley's father. They are separated by the issue of wealth and land ownership.
Through these examples we can see that the ranch hands have a defined "place" on the ranch which serves to isolate them.