How does the setting of "The Interlopers" help highlight the conflict between the man and nature?
Look at what the setting of the story is. First, it is a pretty wild forest. It is, as we find out, a forest that is still wild enough that wolves can live there in pretty large numbers. Second, look at what the weather is like -- there is this big storm that ends up blowing the tree down on the two men.
Once you think of that, it should be clear that this setting is highlighting the idea of man against nature. The men are going out and challenging (and losing to) a very wild setting.
By setting the story in a wild place and bad weather, Saki is emphasizing how much nature can challenge people.