The play also indicates how once a chain of events is set in motion it becomes impossible to undo the past, and, in the case of Macbeth ond Lady Macbeth, leads inexorably to their deaths. As an audience we see the malevolent force of the witches and their suggestions. We witness also the slide of the brave, loyal and virtuous into the maelstrom of deceit and murder.
I agree with earlier suggestions about the fear cultivated in the audience of the ability for all to be swayed along such a destructive path when steered by ambition.
Macbeth's descent into evil recalls Joseph Conrad's "Heart of Darkness" and even Paradise Lost as Satan declares that it is better to rule in Hell than to serve any other. Certainly, evil way leads to evil way--"valuting ambition" leaps further and further into the darkness of Macbeth's heart. This theme of the commitment to evil once one has crossed into the preternatural world is what is most disturbing and fascinating both about Shakespeare's Macbeth, for
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