Metaphase is the stage in both meiosis 1 and mitosis, where the replicated chromosomes, joined together and bound together with centromeres, line up at what is called the equator of the cell. Both phases in each of the two processes appear equally, except the chromatids separate in mitosis, while the chromatids do not separate in meiosis. The homologous chromatids (copied chromosomes) line up by each other, preparing for the next phase, which will be anaphase. In anaphase 1 in meiosis and anaphase in mitosis, there is a difference. The paired chromatids will separate in meiosis, whereas the chromatids will separate where they are bound together by the centromere, and each chromosome will go to its respective cell. So the biggest difference is that the chromatids line up and separate in mitosis, but in meiosis, there is no separation of chromatids. Each new cell receives two chromatids joined together.