I think that George sees Curley's wife as a form of "bad news." This idea of how bad she can be is enhanced by the "vamp" ways in which she carries herself and the reputation she has developed among the other farm hands. George also sees Candy as triggering something else in terms of his relationship with Lennie. The incident that Lennie had back in Weed was the reason that both he and George had to live on the run from there. George is wise enough to understand that a similar situation could result itself with Curley's wife. The significance of how George sees Curley's wife is large because George understands that Curley's wife could present herself as an obstacles to the men's happiness and achievement of their dreams of their own farm. George's view of Curley's wife is something that he wants Lennie to understand in terms of "staying away from her" because she is seen as "bad news." In tihs, George looks out for Lennie, and protects him from harm, a danger that he knows all too well because of how he knows Lennie and what he knows about his past. It is here where the significance of how George sees Curley's wife is present.