In Of Mice and Men, how do Curley's wife , Crooks, and Candy demonstrate that they are lonely ?

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In Of Mice and Men, Curley's wife, Crooks, and Candy demonstrate that they are lonely. First, Curley's wife is a flirt. She flirts with the men on the ranch because she is lonely. Curley often accuses the other men of being inappropriate with his wife. He accuses Slim of improprieties with his wife. All the men insists that Curley keep his wife home:

The men all side with Slim and tell Curley to keep her at home.

Curley's wife is so lonely until she reaches out to Lennie who is mentally unstable. That is how she loses her life. 

Crooks is the only black man on the ranch. He is lonely and ostracized from the rest of the ranch hands. He has to live in isolation from the others just because he is black. When the others play games, he is not invited to play along. When Lennie wanders in Crooks's room, Crooks allows him to stay because Crooks is so lonely. Even though Crooks discourages Lennie from dreaming about owning his own farm one day, Crooks seems to enjoy Lennie's company. 

Candy is another lonely character in the novel. He is so lonely until he invites himself to be a part of George's and Lennie's dream of owning their own farm and farmhouse one day. Candy asks if he con contribute his money and become a part of their dream:

He is sweetly hopeful of joining Lennie and George on their dream farm, offering to contribute his savings of $350 to buy the farm.

Candy feels as if he is becoming old and useless around the ranch. He realizes that one day he will not be needed, just like his old dog who is shot by one of the ranch hands:

Candy is the old, disabled ranch hand who is helpless to stop the shooting of his dog and who knows that he too will be banished when he is no longer useful.

No doubt, Candy desires to belong. That is why he invites himself to become part of George's and Lennie's dream of owning their own farm and farmhouse one day. Sadly enough, when George has to shoot Lennie, Candy knows the dream is over, but he pleads with George to carry out the dream:

“You an me can get that little place cant we George? You an me can go there an live nice cant we George?” 

Truly, Candy is a lonely man who needs George as much as Lennie did.