The more specific the topic of your paper, the better the paper will be and the easier it will be to research and write. That means that you need to formulate some very specific question to ask about Poe's work and then spend some time looking at his work and appropriate background information to develop an answer.
For example, Poe's wife died of "consumption" (what is now called tuberculosis), as did many of his characters. You might investigate the role of consumption in Poe's works. How many of his characters suffered from it? Is his treatment of the disease realistic? What role does it play in his plots? Are there specific types of character who suffer from it?
Another possibility would be to look at incest in Poe. Poe himself married his cousin, and incestuous relationships are discussed or implied in several of his works. You would want also to look at the definition of incest -- there were intense debates in the period about what counted as incest (a cousin? a deceased wife's sister?)
There are many other topics you could discuss, but what is most important is choosing a sufficiently narrow topic so that you can research it and write about it in depth.