U.S foreign policy refers to the goals and policies of the U.S government as it relates to the way we interact with the rest of the world. More specifically, U.S foreign policy changes when new issues arise and when the presidential administration transitions.
The period between 1898 and 1933 is known as the protectorate period as it relates to U.S foreign policy with Spain and its territories in the Caribbean and the Pacific. In 1898, the U.S declared war on Spain and claimed control over their territories. The U.S claimed Cuba, Puerto Rico, Guam and the Philippines at this time. Shortly after the start of the Spanish-American war, Cuba gained complete independence, however the U.S did not relinquish control of the Philippines until 1933, and still controls the islands of Guam and Puerto Rico.
This period is in contrast the Good Neighbor Policy that arose after 1933, under Franklin Roosevelt. This policy was characterized by a hands off approach, and an improved sense of respect and autonomy between the regions.