In 1676, Bacon's Rebellion occurred in Virginia. Nathaniel Bacon led a murderous war against all indigenous peoples of the region in an attempt to further colonize their lands and disempower any indigenous tribes. Bacon's Rebellion attempted to force the colonial government of Virginia to grant him official permission to slaughter any and all native peoples.The rebellion was framed as a just and righteous war against those in power in colonial Virginia, and many poor, indentured, and enslaved people supported and participated in the rebellion for various reasons.
For years, Bacon and his men led a full out genocidal war against indigenous peoples, attacking any tribe they came across, and specifically pushed for killing indigenous peoples regardless of whether the people of a tribe chose to fight back or defend themselves. As this push for all-out-war spread, Bacon encouraged non-native people to view the indigenous peoples not as independent tribes but rather as the same group of people who could be identified using vague stereotyping and racist classifications. When people challenged that there were indeed distinctions among indigenous tribes, Bacon soon replied
Away with these distinctions ... we will have war with all Indians which come not in with their arms, and give hostages for their fidelity and to aid against all others; we will spare none.
Of course, the tribes who were generally seen as the more "hostile" tribes were simply actively resisting an invasion of settlers who were attempting to displace them from their homelands. For Bacon, all indigenous people represented a threat to colonial America and needed to be driven out or slaughtered in order to seize their lands and maintain control.
It was less the official changes in colonial laws that indigenous people had to endure and much more that a powerful rebellion was being brewed, and killing any and all indigenous people was a core component being pushed by the rebellion's leader. However, some laws were passed during the rebellion by the colonial government of Virginia in an attempt to quiet the rebels. Acts were passed that forbid indigenous people from hunting with guns and restricted trade with indigenous peoples. These laws furthered the oppression that indigenous people faced through genocidal colonization.