I assume you mean the impact on Western Europe. The impact of the Columbian Exchange was at best indirect and did not occur quickly. With the Columbian Exchange, the diet of most people in Europe improved substantially, primarily due to the introduction of potatoes, maize, etc. This improved diet resulted in fewer infant deaths and healthier individuals, the result being an explosion in the European population. This population explosion was a direct cause of the Industrial Revolution. The industrial revolution led to the development of a new class, the working class (Marx's "proletariat.") The working class became politically active which resulted in increased participation in politics; a primary example being the increased importance of the British House of Commons.
Diseases were an important element of the Columbian Exchange, but did not lead to significant political impact.