I am not sure if you mean as a business or as an individual. Since both posters have addressed individuals, I will talk about businesses. Businesses can be hurt when their customers go on-line or to other countries to get goods. This can hurt a business, because trying to lower prices can cut into profit margins. However businesses can also take advantage of the global economy by finding new customers. In general, businesses can survive in uncertain times by focusing on their core areas and cutting costs while staying profitable.
I think the above post is correct in saying that you need to be educated. You also must be willing to be flexible in your career. I think at this time jobs are available to the right people, but they may require you to change locations.
In my opinion, the best thing that you can do is to get as educated as possible. I think that Thomas Friedman is right about this when he talks about how to succeed in the globalized "flat" world where jobs can move from place to place so easily.
If you want to have a good job and career in the economy that seems to be developing, you have to be educated so that you have a variety of skills that are useful in performing a variety of tasks. That way, as your job changes, you can adapt. You need to be flexible and I think that the best way to be flexible is to have a good mind that has been taught how to think its way through a variety of problems.
As Friedman says in the edutopia.org link I've added here:
...the most successful people in the 'flat world' will be those who can adapt and learn quickly. The greater our curiosity and passion for learning, the greater chances we will have for success later in life.