How can I compare the relationships in "To Kill a Mockingbird" to those in "The Secret life of Bees"?
First, read the eNotes guide "How to Write a Compare-and-Contrast Essay"; click on the link in the Sources section. You'll get great advice on how to write a thesis statement and what sorts of things to look for in the stories you're wanting to compare.
You might want to focus your comparison on the two girls and how they relate to the people around them. In both books, the girls live in single-parent homes with a father and are raised by an African American maid. What is Lily's relationship with her father? How does it compare to Scout's relationship with Atticus? How are Lily and Rosaleen different from Scout and Calpurnia? Does Lily have any other family members--aunts, cousins, siblings? Who does Lily seem to be more comfortable with? How does each girl relate to members of her community?
Think about these questions, and more that will come to you, and I'm sure you'll do fine.
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