Although "Freak the Mighty" is written for approximately fifth through seventh grade students, it contains some fairly serious themes. Focusing on the events of each chapter rather than the themes might be easier for students who aren't fluent in English, and because it is a fairly easy read, should not be difficult to write. Many study guides for novels will contain far more questions per chapter than are really necessary for understanding the story, and if assigned in their entirety, might turn students off to reading the story altogether. Whether the students are ESL students or not, end of chapter questions should probably be kept to a minimum to promote student engagement.
For this novel, thematically, it is important to understand the less than ideal backgrounds of each boy, what each could offer the other in terms of strengths and weaknesses (Kevin was physically disabled, but intellectually brilliant and imaginative, while Max had physical size, but struggled in school), and how in a short amount of time, Kevin enriched and changed Max's life for the better, a change that endured even after Kevin passed away. Chapter questions can be tailored to helping students understand these aspects of the story if one avoids lower order questions over minutiae such as what color of shirt someone was wearing (for example).