The story that comes immediately to mind is John Steinbeck's story that is called "Flight." In it, Pepe is drawn by fate and circumstances into killing a man. Pepe is poor, uneducated, and powerless. As a result of his situation, his only course of action is to run, to flee into the nearby mountains to escape those who will surely pursue him and kill him. In the story, those who pursue Pepe are called "the dark watchers." Despite his efforts, Pepe cannot escape. He dies, suffering and alone.
Another, more subtle example of flight as representing escape and freedom can be found in A Separate Peace by John Knowles. The novel is set at Devon, a prep school in New Hampshire, during World War II. In that novel, the main character, Gene, has betrayed his best friend Finny and suffers from guilt and fear, as a result. Gene's emotional turmoil becomes so great at one point in the novel that he decides to enlist in the military. Gene sees going to war as a means to escape being trapped by the past, and he believes that leaving Devon behind will bring him freedom and relief from his punishing emotions. As it happens in the story, he does not leave, however.