In the second act of Macbeth, the major hint that suggests the tragic fate of Macbeth and Lady Macbeth is Macbeth's rant about "murdering sleep." In the second scene, Macbeth has rejoined his wife after having killed King Duncan, and he is worried that someone has heard him commit the crime. Lady Macbeth assures him that he is overreacting, however, Macbeth cannot rid himself of his fears. He then says that he has "murdered sleep," meaning that this grave crime will not allow him to have any peace for the remainder of his life. This suggests that Macbeth's crime will continually haunt him. And although Lady Macbeth is relatively calm and cool in this scene, Macbeth does say that the evil has fallen on their home, so this implies that Lady Macbeth will also not have any peace for the remainder of her life. Later acts in the play prove this to be true.