It's act 2, scene 6 of Romeo and Juliet, and the title characters are on the brink of getting married. Friar Laurence is on hand to perform the honors, to make the two young lovebirds' relationship respectable in the eyes of the Church.
Not long before the ceremony begins, the Friar expresses the heartfelt wish that the heavens will smile upon the forthcoming nuptials and that nothing will happen in the fulness of time to make anyone regret that the marriage took place.
Romeo agrees with a hearty "Amen, amen." But he goes on to say that, whatever misfortunes should befall the young couple, they will never be able to ruin the immense joy that Romeo feels whenever he casts eyes upon his beloved Juliet. Not even death—"love-devouring death," as Romeo calls it, the death that destroys love—matters in the overall scheme of things.
What does matter—indeed, the only thing that matters to Romeo—is that he can say that Juliet belongs to him: that "I may but call her mine." All that Romeo requires of Friar Lawrence, then, is for him to join him and Juliet together in holy matrimony, to "close [their] hands with holy words." After that, whatever will be, will be.