The factors that effect bio compatability are as follows:
biomaterials interact with the human body and eventually how those interactions determine the clinical success of a medical device (such as pacemaker, hip replacement or stent). Modern medical devices and prostheses are often made of more than one material so it might not always be sufficient to talk about the biocompatibility of a specific material.
The immune response and repair functions in the body are so complicated it is not adequate to describe the biocompatibility of a single material in relation to a single cell type or tissue.
Biomaterials can generally be produced either in nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components or ceramics. They are often used and/or adapted for a medical application, and thus comprises whole or part of a living structure or biomedical device which performs, augments, or replaces a natural functions, so to say what the effect of each bio compatibility is , it differs, because the elements and the process of it being made is altered.