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Of the Enlightenment philosophers Locke, Berkeley, Hume, and Kant, which was the most influential with respect to description of the nature of reality? 

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Hume, in combination with Kant—who was strongly influenced by him—changed the whole nature of how reality is perceived. Hume's unrelenting skepticism effectively destroyed the pretensions of metaphysics to arrive at any reliable picture of reality. As traditionally conceived, metaphysics, according to Hume, was unable to do this because it was grounded in supernatural assumptions and as such could tell us nothing about the empirical world around us, which for Hume is the only source of reliable knowledge. For Hume, the arch-empiricist, knowledge comes from sense experience and the faint impressions they leave in the mind. In his thought, there is no place for a priori metaphysical postulates as they are purely products of the mind, not related in any way to empirical experience.

As we've already seen, Kant was very much influenced by...

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