The role of nature, in Mary Shelley's novel Frankenstein, presents itself as one of the major themes depicted throughout the novel. While Elizabeth is far more enamored by nature, "She busied herself with ... the sublime shapes of the mountains; the changes of the seasons; tempest and calm; the silence of winter, and the life and turbulence of our Alpine summers," Victor was far more enamored with science.
For example, when Victor first became overly interested in science, a lightning strike to a tree was responsible for peaking Victor's interest. Instead of being drawn to the natural elements of nature, Victor was drawn to the scientific aspects of it.
I never beheld anything so utterly destroyed. Before this I was not unacquainted with the more obvious laws of electricity.
Unlike Elizabeth, who would have been intrigued by the power of nature, Victor ignores the power and, instead, focuses upon the scientific aspects of it. Victor proves, again and again, that the natural world is of no importance to him. His utter dismissing of nature proves to be his tragic flaw in the end.
Although Victor tends to ignore nature, nature does not ignore Victor. it seems that every time Victor falls into his incurable illnesses (seen after he creates the monster, after William, Justine and Clerval's deaths), nature is what brings him out of his despair. Therefore, although Victor fails to recognize the importance of nature, nature never once backs down from Victor (showing its power to regenerate season after season and remain unchanged no matter how much time has passed).