Does the citric acid cycle require oxygen?

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Yes, the citric acid cycle does require oxygen for the process. The citric acid cycle is central to metabolism and critical to the electron transport chain, which is where most ATP is produced. While oxygen is not directly used in the citric acid cycle it is needed for the electrons in the process to recycle NADH back into NAD+ and recycles FADH2 back into FADH which are required enzymes in the citric acid cycle. Additionally if oxygen within the cell is low the cell will be required to result to fermentation to continue making ATP which is required within the cell to transport energy for metabolism.

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