Well, that's a very interesting question. At present, brain neurology research is focusing on socially relevant functions. I'm sure there are many fields of brain research I am unfamiliar with, but this one area I am slightly acquainted with. The emphases of the studies I'm thinking of are on how to address some of our most demanding socio-cultural problems.
For example, research on trauma induced fear has identified two means of erasing newly implanted traumatic fear memories: one method uses extinction, one uses propranolol. Another group of studies focuses on memory enhancement and extension: chocolate, green tea and red wine (for those of legal drinking age) provide the flavonoid epicatechin that facilitates enhancement and extension.
These groups of researchers are addressing current socio-cultural needs: post-traumatic war syndrome and Alzhiemer's disease. With this in mind, relevant to these sub-fields, it seems to me that personality related neuro-science will be further down in the queue of relevance--unless it is seen as critical to our education crisis--so I suspect there will be no immediate elimination of the need for personality paradigm theory.