Well, we do know that the decision to leave USA, sell his farm and move to England in pursuit of literary recognition must have been an absolutely massive decision to make, as it involved a complete change for the life of the poet. This notion of making a life-changing decision would fit in well with the overall theme of this excellent poem, which is all about the decisions that we make and how they lead on to other decisions, and also how we can rarely go back and make another decision in place of one that we have made. This would make your idea very attractive, if we consider that Frost may have written this poem looking back on his decision to leave the USA and his farm and go to Europe. Note the final stanza that could be used to support this idea:
I shall be telling this with a sigh
Somewhere ages and ages hence:
Two roads diverged in a wood, and I--
I took the one less travelled by,
And that has made all the difference.
The "sigh" that the speaker anticipates he will be narrating his story with indicates the way in which he is haunted by his decision but also what would have happened had he selected the other road. There is no clear indication that Frost wrote this poem specifically about his own decision to leave the USA but certainly we can consider that this might be what prompted him to write such a meaningful and incredible poem.