I assume you are asking about internal organs and general structures. For the most part the answer is no, they do not drastically differ. Obviously, the male and female sex organs are different and the coinciding internal structures are different. Females have ovaries that produce eggs. Males have testicles that produce sperm. Both men and women have a gastrointestinal tract(GI) that functions the same in both genders. Both have a neurological system that functions the same. Both have a cardiovascular system that functions the same. Both have a renal system that functions the same.
There are more internal similarities than differences. Generally, the size of the organs in men is slightly larger as is stature.
Hormonal action in men and women in most regards is the same but there are also vast differences especially in the reproductive area.