difference between tolerance and reasons Differentiate between drug disposition tolerance, behavioral tolerance, and pharmacodynamic tolerance, and provide reasons why these concepts should be...

difference between tolerance and reasons

Differentiate between

drug disposition tolerance, behavioral tolerance, and pharmacodynamic tolerance, and provide reasons why these concepts should be taken into account when determining the effects of a drug.

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megan-bright's profile pic

megan-bright | (Level 1) Associate Educator

Posted on

Drug tolerance involves both psychological and physiological factors. Physiological tolerance occurs when a subject's reaction to a specific drug and concentration of the drug is progressively reduced, requiring an increase in concentration to achieve the desired effect.

accessteacher's profile pic

accessteacher | High School Teacher | (Level 3) Distinguished Educator

Posted on

Of course, drug disposition tolerance is very concerning as addicts get used and accustomed to the drugs and the impact is not as strong as it was to begin with. This drives them to seek ever greater quantities or purity of the drug in question which of course exacerbates both their addiction and their situation.

kplhardison's profile pic

Karen P.L. Hardison | College Teacher | eNotes Employee

Posted on

Drug disposition tolerance occurs when more enzymes synthesize in the presence of the drug in question (precursor inhibitors are removed). This leads to rapid deactivation or excretion. This enzyme synthesizing process, and an increase therein, is what leads to the need for an increase in the amount of the drug to achieve the past/desired effect.

litteacher8's profile pic

litteacher8 | High School Teacher | (Level 3) Distinguished Educator

Posted on

I would say the most important thing to take into account is that some people will not develop tolerance to the drug. Not everyone's metabolism is the same, and some people are extremely sensitive while others seem to be resistant to any effects at all.
pohnpei397's profile pic

pohnpei397 | College Teacher | (Level 3) Distinguished Educator

Posted on

Behavioral tolerance is when a person learns how to behave differently to compensate for the effects of the drug.  It is a learned thing.  Drug disposition tolerance is physical, not learned.  It is when the body neturalizes and/or excretes the drug more rapidly when the drug has been administered a number of times.  In both cases, higher doses may be needed.

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