It depends how you are using this word. Shakespeare used it as a verb, but we seem to understand it as a noun.
It directly mean to bury, according to Shakespeare. However, I could easily see it used as burial, or burial location.
Here's how I would use it each way.
The serial killer had to sepulcher each object with any DNA connecting him to the murder in order to hide the evidence of his crime.
The sepulcher was off the dirt road, down the hill and across a dreary churchyard strewn with tombstones and decaying flowers.
See if those work for you.