It depends how you are using this word. Shakespeare used it as a verb, but we seem to understand it as a noun.

It directly mean to bury, according to Shakespeare. However, I could easily see it used as burial, or burial location.

Here's how I would use it each way.

The serial killer had to sepulcher each object with any DNA connecting him to the murder in order to hide the evidence of his crime.

The sepulcher was off the dirt road, down the hill and across a dreary churchyard strewn with tombstones and decaying flowers.

See if those work for you.

My experience with the term is from the poem by Edgar Allen Poe, Annabel Lee.  The use of the term comes from the lines, "To shut her up in a sepulchre/ In this kingdom by the sea."  In this context, the term "sepulchre" is used to mean a type of cage or confinement, almost dungeon like.  I believe it can be used to describe a tomb, or some type of vault for the dead.  Along these lines, it can be used as an adjective to describe something gloomy or Gothic.  For example, "The work was very sepulchral," which would refer to its gloomy and despondent nature.  The idea of the term having a death denotation is  very evident.

A sepulchre is simply an old style tomb.  It is like a vault or something that is more like a room or a building than like a modern grave.  In the sepulchre you can have the coffins of more than one person, usually from a family.  So there you have a couple of sentences with the words sepulchre in them.  A couple of other ones:

• They took his body and laid it in a coffin in a sepulchre.
• The word "sepulchre" is used seventeen times in the plays of William Shakespeare.