Contrast the characters of Octavius Caesar and Mark Antony. What is the major theme of the play Antony and Cleopatra?

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Shakespeare offers an excellent contrast between the characters of Octavius Caesar and Mark Antony in Act 2, Scene 3 of the play. Antony asks the Soothsayer whose fortunes will rise higher in the future, his or Caesar, and the Soothsayer replies as follows:

Therefore, O Antony, stay not by his side:
Thy demon, that thy spirit which keeps thee, is
Noble, courageous, high, unmatchable,
Where Caesar's is not; but near him thy angel
Becomes a fear, as being o'erpower'd: therefore
Make space enough between you.

Speak this no more.

To none but thee; no more but when to thee.
If thou dost play with him at any game,
Thou art sure to lose; and of that natural luck
He beats thee 'gainst the odds: thy lustre thickens
When he shines by: I say again, thy spirit
Is all afraid to govern thee near him;
But, he away, 'tis noble.

Caesar is shrewd, cunning, cautious, secretive, watchful, selfish and calculating. Antony is notorious for his hedonism. He loves sports, drinking, eating, carousing. In Julius Caesar, Cassius calls Antony "a masker and a reveller." Antony is, as the Soothsayer tells him, a bigger and better man than Octavius Caesar in most respects. He is more courageous, a much better soldier, generous, a good friend and a passionate lover. But Caesar wins out in the end because he is a younger man, whereas Antony has passed his prime and is on a downhill course which is accelerated by his obsession with Cleopatra. Going to Egypt was probably the worst thing Antony could have chosen, because the queen and her kingdom are notorious for orgies and dissipation, the kinds of pleasures that Antony has always loved. Antony's dominant character trait is emotion; Caesar's dominant character trait is intellect. Antony relies on intuition. He is impulsive, rash, spontaneous. Caesar seems cold-blooded in comparison to Antony. Caesar really despises sensual indulgence because it interferes with his ability to reason. In all of his dialogue in the play, Caesar seems cool and self-possessed. Whatever feelings he has he keeps to himself. It is no wonder that Caesar, as the Soothsayer remarks, beats Antony at any game. Caesar is a man who "plays his cards right." 

The main theme of Antony and Cleopatra is introduced in the very first lines of the play by a minor character named Philo:

Nay, but this dotage of our general's
O'erflows the measure: those his goodly eyes,
That o'er the files and musters of the war
Have glow'd like plated Mars, now bend, now turn,
The office and devotion of their view
Upon a tawny front: his captain's heart,
Which in the scuffles of great fights hath burst
The buckles on his breast, reneges all temper,
And is become the bellows and the fan
To cool a gipsy's lust.

[Flourish within.]

Look where they come:
Take but good note, and you shall see in him
The triple pillar of the world transform'd
Into a strumpet's fool: behold and see.

The main theme has to do with the downfall of a famous historical figure whose fortitude and acumen are undermined by a fascinating but destructive woman who is an equally famous historical figure. Cleopatra manipulates Antony to serve her own purposes. He is totally infatuated with her. He makes fatal decisions because of her. He marries Caesar's sister Octavia in order to cement his relationship with Caesar, but then he outrages both of them by returning to Egypt and resuming his lustful and riotous behavior with Cleopatra. Antony seems to know that he is on a fatal course but is powerless to change his ways at this late stage of his life. Caesar is twenty years younger than Antony; he is on his way up, whereas Antony is obviously on his way down. 

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