Certainly, the Native American populations at the time would have viewed Christopher Columbus as a 'foe.' If anyone were to read Columbus' journal entries, he immediately begins thinking of ways the native populations might be of use to him:
"It appears to me, that the people are ingenious, and would be good servants and I am of opinion that they would very readily become Christians, as they appear to have no religion" (Columbus Journals).
His first thought is to make them his servants, and his second is to convert them to his religion, and Columbus was not alone in his thinking. The predominant thought by most of the Europeans was to capitalize on the new found resources of the New World, including potential human labor. From the human rights angle, the colonization of the New World was disastrous, resulting in the enslavement of large masses of people, both Native American and African, as well as the massive death toll brought on by small pox and cholera epidemics.
With that being said, the discovery of the New World also brought with it some amazing advances and progress like the Columbian exchange that introduced massive amounts of new types of food and produce to the European market. Moreover, the new lands created vast social and economic opportunities that stimulated trade and allowed for colonization, eventually leading to the development and creation of the thirteen colonies and gradually, the United States.