In Chapter V, Shelley largely presents Victor's disappointment with his creation through his newly-developed revulsion to science. Though he was once obsessed with the acquisition of scientific knowledge, he now abhors anything having to do with scientific pursuit. He says,
Ever since the fatal night, the end of my labours, and the beginning of my misfortunes, I had conceived a violent antipathy even to the name of natural philosophy. When I was otherwise quite restored to health, the sight of a chemical instrument would renew all the agony of my nervous symptoms.
Victor had become extremely ill after the "birth" of his creation, and his best friend, Henry Clerval, nursed him back to health. Even now, however, the subject of science is intensely painful for him. Professor Waldman compliments Victor on his progress, and this, too, makes Victor very uncomfortable. His inability to bear the sight of chemical instruments or accept praise for his work in this field conveys just how much he hates anything to do with his experiment. After all, it nearly killed him.
In the months that follow, Victor's health -- both physical and mental -- improve dramatically as a result of Henry's influence. Henry is imaginative and has no interest in science. Victor credits Henry with restoring him to life, a life he claims was almost taken by his obsession with his creation:
Study had before secluded me from the intercourse of my fellow-creatures, and rendered me unsocial; but Clerval called forth the better feelings of my heart; he again taught me to love the aspect of nature, and the cheerful faces of children [....]. A selfish pursuit had cramped and narrowed me, until [Henry's] gentleness and affection warmed and opened my senses; I became the same happy creature who, a few years ago, loving and beloved by all, had no sorrow or care.
We can see Victor's disappointment with his creation by his response once he is free of it. He recognizes that he was miserable while working on it, that this work isolated and alienated him from his family and friends, from nature, from all the things that make his life worth living. His disappointment with the creature, in this chapter, has much more to do with the effects of his obsessive work rather than anything about the creature himself. And, in true Victor fashion, he is incredibly self-centered, thinking only of how his experiment nearly ruined him, neglecting to spare a thought for the creature which had vanished from his apartments just a chapter before.
In this chapter, Shelley doesn't directly present readers with confirmation of Victor's obsession with ridding the world of his creation. What she shows us, instead, is just how happy Victor is when he believes himself to be free of it. In the final line of the chapter, Victor says that, at this time, "[His] own spirits were high, and [he] bounded along with feelings of unbridled joy and hilarity." He has been able to forget his creature, and his life is restored to its former felicity. We can assume, then, that any reminder of that science -- most especially, coming face to face with the creature himself -- will drive Victor immediately into the depression and horror he felt immediately after his creature was complete. Of course he would want to rid the world of his creation at that point because the creature would be a constant reminder of Victor's own shortcomings and lack of forethought.