Carol Beth is extremely afraid of becoming a wrinkled old crone. She never steps outside without out an SPF 75 sunscreen on. Her sunscreen contains PABA which is converted by sunlight to GABA which a very potent CNS inhibitory neurotransmitter. She has been experiencing weakness in her muscles, slow reflexes in her periphery and cannot make decisions well. Her blood work shows a very low vitamin D level, decreased blood calcium and high levels of circulating GABA. It is a perfect storm—what two things are happening to her neurologically and how are they related to her sunscreen use? (Be very specific with your terminology—ie. make, synthesis, create, absorb, inhibit)
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GABA (gamma-Aminobutyric acid) is an inhibitor in the central nervous system present in most mammals including humans. It is naturally occurring in the body which directly functions to reduce the neural activity of the nerve cells to where it resides. Basically, GABA relaxes the body, controls fear and anxiety and to help in the stimulation of pituitary gland for secretion of hormones necessary for growth and development.
In the case of Carol Beth, there are several reasons for the cause of imbalances in her body. Excessive use of sun block lotions can decrease the production of vitamin D which is the primary help in the absorption of calcium in the body. So without sufficient levels of vitamin D in the body, the calcium supplement will be useless.
The high GABA content in her body can be due to different factors. She may be taking food supplements with GABA because since it is believed to have effects on the skin. The use of sunscreen that contains PABA which is later converted to GABA is not feasible to enter the blood stream through the skin. The effects of excess GABA to her are the weakness of her muscles and slow reflexes.
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