Can you give me another way to say the following? I want to say: "Hopelessness can make life unhappy." 

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mwestwood eNotes educator| Certified Educator

Why not use metaphor as Emily Dickinson has done in her poem about hope whose first stanza reads,

“Hope” is the thing with feathers -
That perches in the soul -
And sings the tune without the words -
And never stops - at all ....
Hopelessness is the same as despair, so you can also use the word despair, which is derived from the French noun l'espoir and the prefix de- which means "out of." To say that life becomes unhappy when one has a sense of hopelessness can easily be expressed metaphorically; and, by doing so, the student can create an unusual comparison with "Despair" just as Miss Dicksinson has done with "Hope." Here is an example of the use of extended metaphor,
Despair [or Hopelessness] is a dark cloud
Looming over the heart,
That will not rain forth aloud,
Or muster wind enough to depart,
But shadows the soul with its lifeless gloom throughout.

OR--Here is an example of a simple metaphor (life=gloom) used in a declarative sentence: 
Hopelessness can loom so darkly over the heart that one's life is none but gloom.
readerofbooks eNotes educator| Certified Educator

There are many different ways to say the same thing. Some ways are more creative than others. So, I will give you several different versions. 

A simple inversion of the sentence is a follows: "An unhappy life is often caused by hopelessness."

Another version is as follows: The one who has no hope in life may be unhappy." 

A more pithy was of saying this is: "unhappiness is rooted in hopelessness." 

Here is a more figurative way to say it: "Hope leads to happiness, but hopelessness leads to unhappiness."

These version should get you started.