can someone help me write a great thesis for an essay about friendship in Of Mice and Men?

You should treat your thesis or topic sentence as the main point of your essay. You'll want to make sure that everything you write supports this main point. By doing this, you'll make sure to include all of the necessary information and won't forget anything. However, if you're writing about a friend, family member, or someone else close to you, it's important to remember that not everything is always black and white. Not everything is so simple that you can just find an example from a book where two friends have a great relationship and apply it to your own life. Don't be afraid to complicate some things up!

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Depending on the requirements for the essay, you might focus your essay on the idea that Of Mice and Men shows the complexity of friendship. Typically, when we think of two people who are friends, it's very clear how those friends should treat each other. George and Lenny, however,...

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Depending on the requirements for the essay, you might focus your essay on the idea that Of Mice and Men shows the complexity of friendship. Typically, when we think of two people who are friends, it's very clear how those friends should treat each other. George and Lenny, however, have a very unique relationship. They may be the best friend each other has, but George also looks after Lenny, which makes things complicated. He has to be a disciplinarian and keep Lenny in line while also treating him as a friend. At time, George is even frustrated with Lenny and questions whether he would be better without him. Lenny, on the other hand, looks up to George unwaveringly and never questions his friendship. 

Your thesis might look something like this:

In the novel Of Mice and Men, John Steinbeck uses the relationship between George and Lenny to show that friendships, while strong, may not always be easy and can be quite complex for one or both of the parties involved.

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You might consider writing about how friendship, in this novel, has the potential to overcome social forces that diminish human value and isolate individuals from one another.  The dream of buying a farm and raising rabbits is not just a dream of material success. It is a dream, for Lennie, George, Candy and Crooks, of a situation where friendship and togetherness is secure, certain and permanent. 

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I always say a thesis should directly address the prompt.  I am not sure what your instructions were.  However, I agree that friendship is represented in different ways in the book.  Your thesis should specifically address one.  Here is an example.

In the novel Of Mice and Men, Steinbeck explores how friendship involves friends looking out for one another.

In this case, George always looked out for Lennie. 

"Sure," said George. "We kinda look after each other." Hendicated Lennie with his thumb. "... Hell of a nice fella, but he ain't bright. I've knew him for a long time." (ch 2)

George calls Lennie a "nice fella" and appreciates his work ethic.  They have always traveled together, because it's nice to have someone.  Friendship is an antidote to lonliness.

Even when he shoots him in the end, he is looking out for him.

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