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In Mary Shelley's novel, Frankenstein, the theme of isolation applies primarily to the creature (though it will also apply to Victor later in the story).
Media refers to...
...the means of communication, as radio and television, newspapers, and magazines, that reach or influence people widely...
I believe isolation could relate to several media components depending upon how they are used. The idea that these components "reach or influence people widely" would indicate that with normal usage, isolation would not occur. Under certain circumstances, however, we can find situations that would actually promote isolation.
For instance, if a computer does not have Internet capabilities and someone used it only to play games, this would promote isolation for the user. (Video games that have no interactive capabilities would primarily do the same thing. Someone could play hours and hours of video games, finishing one and moving to another, further isolating themselves if this is all they did—though these gaming consoles are probably not considered forms of media.)
In terms of magazines or newspapers, and television, if someone only read or watched one kind of magazine or one kind of television programming, this might cause a form of isolation. The creature in Frankenstein is not always alone: he does live in the shed attached to the De Lacey house, and he learns a great deal. He is still able to interact through observation with society to a certain extent, but only in secret by listening and watching. The creature's truth depth of isolation is quite evident, however, when the family sees the monster for the first time.
Because media generally refers to things that allow communication, I would expect that the computer without Internet capabilities would be the best example of a media component that would lead to deep isolation. However, if one listened to programming that was geared only to right-wing listeners, or left-wing listeners, or the magazine or newspaper they read was completely biased in one direction, then a person's isolation would be from part of the world, in that the person was only exposed to parts of the world—not the whole.
These suggestions are the only ways I can perceive media components lending themselves to complete, or at least partial, isolation.
If you mean that you'd like to make a thematic link from one text to another "media" text, then I'd suggest the song "That's Okay" by the Hush Sound. I'm sure there are millions more that I could suggest; I happen to be a fan of said band. I'd love to help more, if you wanted to clarify the meaning of your question.