The short story has been adapted countless times in so many different ways. It's inspired video games, movies, tv shows, and much more. Take a look at the wikipedia list of adaptations for a very comprehensive rundown of direct adaptations, and 'inspired by' books, movies, games, etc.
What do you think are the best adaptations? I liked Stephen King's story The Running Man along with the movie which starred The Governator himself.
A more indirect (and gruesome) adaptation of this story can be seen in The Silence of the Lambs, in which a sadistic serial killer is used to try to hunt down another sadistic serial killer. The idea is that it takes on to know one; who better to know the animal being hunted than one who also hunts that animal. That kind of expertise is, after all, how Rainsford managed to outwit and eventually kill General Zaroff.
Talking about adaptations, let's consider the innocent childhood game of hide-and-seek. This is "The Most Dangerous Game" at its most innocent and humble beginnings. Remember the times you would do anything to trick your "prey" into revealing themselves so you wouldn't have to be it? Remember how your heart would pound in fear and anticipation of being discovered and running back to "base" before you get tagged?
Even "Gilligan's Island" adapted the story for an episode. A big-game hunter and his sidekick landed on the island to hunt whatever lived on it and discovered the castaways. That's when he decided to hunt "the most dangerous game": a human. He chose Gilligan, but he made a deal with the group that if Gilligan could elude him for 24 hours, he'd take them off the island with him. Of course, Gilligan managed to live, but the hunter was so embarrassed that he had been outsmarted that he backed out of his deal.
Gee, I'm really embarrassed that I remember that!!
A really sick type of adaptation, but it instantly reminded me of the story was the movie Hostel where teens kind of trapped other teens that were traveling abroad and brought them to a sort of torture warehouse. Once inside the warehouse, wealthy people could pay to murder. The business ads ran like it was some exclusive elite hunting club, but it existed solely for those wealthy people who always wondered what it would be like to torture or murder a human being without fear of being caught.
The parallels, obviously that humans are killing humans, but also the fact that the tortured and murdered (the "huntees") were trapped into this sort of game without knowledge of what they had gotten into. I also thought that the hunters were like General Zaroff in that they feel justified in committing the act because they are rich and civilized and feel a sense of entitlement to do this because of who they are.