Yes, loving God makes a difference to the way Christians live their lives. Scripture makes clear that a properly-ordered Christian life begins with loving God and placing him as one's top priority. There are several evidences for this claim.
First, God began the 10 Commandments by exhorting the Israelites that "You shall have no other gods before me (Exodus 20:3, English Standard Version). Without placing God at the center of their lives, his people would conduct very different lifestyles (as is evidenced throughout the Old Testament when the Jews forsake God for the pagan gods of the surrounding peoples).
Second, Jesus said that the first and greatest commandment is to: "love the Lord your God with all your heart and with all your soul and with all your mind" (Matthew 22:37). He goes on to say that this commandment, along with the exhortation to love one's neighbor as himself, serves as the foundation for all of Scripture. Thus, to not love God would cause a Christian to misunderstand the Bible and to live a life which was in contradiction to it.