I think that more detail in the question is needed in order to successfully render an answer that will assist you. The first issue into which I would have to delve deeper would be what type of literature is going to be the basis of the seminar. What would be offered up in terms where the discussion is going? What situations are you analyzing in terms of identifying the struggle for freedom? I think that it might help your seminar and your discussion by being able to discuss specific personal examples from those participating as to a moment in their own lives where the struggle for personal freedom was most important? What was the situation? What did freedom look like? What were the obstacles being battled? I think being able to open with this exploration and then being able to transfer this to the specific context of man's freedom through literary analysis might be able to provide a strong sense of structure to your seminar.
This theme can be attempted historically looking at the history of de-colonization in the latter half of the 20th century for example. The notion of a mass-movement, elite versus people's politics, anti-colonial nationalism and an ironic and hidden persistence of colonial hegemony in neo-colonial terms, the problem of the subaltern---all these issues can be approached.
The theme can also be treated philosophically e.g. the existentialist notion of freedom and Sartre's ideas on it or going further back, for that matter, into the Greek notion Eleutheria.
The theme can be seen politically from a broadly socialist point of view with notions of class struggle, leading to revolution and the withering away of the state along with a re-establishment of the ancient classless society.
Social Darwinism in the struggle for existence and the survival of the fittest via natural selection can be yet another paradigm.