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MacDuff and Macbeth's reactions are not similar; in fact, I would say that they are almost polar opposites. MacDuff shows genuine grief at the news of his family's murder and is practically over-wrought with emotion, so much so that Malcolm has to talk him down. Macbeth, on the other hand, hears the news of Lady Macbeth's death and is so caught up in his own war plans that he remarks that she could have picked a better time!
I will say that one similarity between the two is location. Both characters are removed from the scene of their wives' deaths. Neither is present when the wife actually dies, and both men are removed from their families at the time because of the conflict over the crown.
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