What this statement means is that Hamilton was regarded by many Americans as someone unconcerned with the economic well-being of the little guy.
Opponents regarded Hamilton as an elitist, a man who didn't have much regard for ordinary Americans. In this regard, they pointed to his plans for raising revenue, which involved imposing tariffs on domestic items such as whiskey. Such measures were regarded as an attack on small farmers, the very same people who voted for Hamilton's political opponents.
At that time, most Americans worked in agriculture, and so it was easy for Hamilton's opponents to make the charge that, in his economic policies, he was ignoring the well-being of the vast majority of Americans.
But Hamilton wasn't concerned by such criticisms. He wanted America to become a modern industrialized country with a strong manufacturing sector. It was this single-minded focus on the bigger picture more than anything else that led critics to accuse him of being more enamored of America than of his fellow countrymen.