After the War of 1812, the United States’ economy became more of a national economy.  This helped cause some degree of sectional strife.  There were at least two issues that are good examples of this strife.

First, there was the conflict over the Second Bank of the United States.  This conflict did not exactly break down along North-South lines.  Instead, it was more of a conflict between the more settled parts of the country and the less settled parts.  The people of the less settled areas did not like the bank as they thought it was a way for the elites to exploit them.

Second, there was the conflict over the tariff.  This issue did break down along North-South lines.  The North had an economy that was somewhat industrialized.  Northerners generally liked the tariff because it prevented European products from competing with their own.  By contrast, the South disliked the tariff.  Its economy was based on trade as it sent cotton to Europe and imported many goods.  This meant that a tariff helped the North and hurt the South.   The conflict over the tariff led to the Nullification Controversy between the North and the South.

These were two major conflicts that occurred between sections of the country due to the nationalization of the economy after the War of 1812.