In the 1500s, the majority  of the Native American peoples who died did so not because of warfare but because of ..... brought by the Europeans.

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ms-mcgregor eNotes educator| Certified Educator

One of the major reason the Native American societies declined so rapidly after contact with the Europeans was the introduction of Old World diseases such as smallpox, measles, chickenpox, and mumps to to the New World. By 1920, only 270,995 Native Americans remained on the continent. They were the survivors of an estimated 1.2 million to 18 million Native Americans who lived on this continent prior to the arrival of the Europeans. Much of the population was lost to diseases for which Native Americans had had no prior exposure to these plagues and their immune systems were inadequate to fight them. However, it is important to not that North America itself was not completely disease free when the Europeans landed. There is much biological and archaeological evidence that Native Americans suffered from malnutrition,tuberculosis, anemia and other illnesses which, of course, affected their general health even before the Europeans landed. This general state of health, coupled with new diseases and changes in the ecology of the land also contributed to the great decline in Native American populations.

sheteaches | Student

Smallpox was the cause of the death of the Native Americans in 1500's.