How did the Muslims in Mindanao react to the Spaniards?  

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Basically, the Muslims in Mindanao (or Moros) resisted the Spanish and did so very effectively.  Their resistance was strong enough that there was still fighting going on when Spanish rule ended.

By the time the Spanish started to try to conquer the Philippines (they held Manila, but wanted to spread...

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Basically, the Muslims in Mindanao (or Moros) resisted the Spanish and did so very effectively.  Their resistance was strong enough that there was still fighting going on when Spanish rule ended.

By the time the Spanish started to try to conquer the Philippines (they held Manila, but wanted to spread their control over more of the archipelago) there were fairly strong Muslim sultanates in the Southern Philippines, notably on Mindanao.  The Moros fought against the Spanish and were able to hold them off to a large degree.  The Spanish were able to establish strong outposts like Zamboanga, but they were never able to completely control the Moro countryside.

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