Daffos Uses Blood Taken Through the Umbilical Cord to Diagnose Fetal Disease (Great Events from History II: Science and Technology Series)
Article abstract: Daffos used ultrasound to guide needle placement into the umbilical cord to withdraw pure fetal blood for rapid prenatal diagnosis of disease in the fetus.
Summary of Event
The team of Fernand Daffos, Martine Capella-Pavlovsky, and François Forestier developed a new and improved technique for collection of fetal blood samples in 1982, which they reported after numerous successes in 1983. Pure samples of fetal blood were obtained from the large vein in the umbilical cord, using a long, twenty-gauge spinal needle that was guided by real-time ultrasound imaging. The transducer of the ultrasound apparatus was held immobile at the point of needle entry on the mother’s abdomen, and it showed the location of the needle with respect to the placenta, fetus, and umbilical cord. Blood was collected from a point on the cord about 2.5 centimeters from its connection to the placenta, into a syringe attached to the needle. Between 1 and 2 milliliters of blood was collected in each case. The new procedure was a dramatic improvement in fetal blood collection, as compared to other methods in use at the time for prenatal diagnosis of disease in the fetus.
Prenatal diagnosis of numerous genetic defects can be done by various means, including laboratory examination of blood, skin, or amniotic fluid cells from the fetus. For different suspected disorders, different methods and tissues work better. A common...
(The entire section is 2313 words.)
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