Acrocallosal syndrome (Encyclopedia of Genetic Disorders)
Acrocallosal syndrome is a rare congenital disorder in which the individual has absence or only partial formation of the corpus callosum. This is accompanied by skull and facial malformations, and some degree of finger or toe malformations. Individuals may display motor and mental retardation. The cause of this genetic disorder is unknown, and the severity of the symptoms vary by individual.
Acrocallosal syndrome was first described by Schinzel in 1979, and also may be referred to as Schinzel acrocallosal syndrome. The term acrocallosal refers to the involvement of the acra (fingers and toes) and the corpus callosum, the thick band of fibers joining the hemispheres of the brain. Reported in both males and females, the cause of the disorder is unknown. The major characteristic of the syndrome is the incomplete formation (hypoplasia) or absence (agenesis) of the corpus callosum. Facial appearance is typically similar among affected people. This includes a prominent forehead, an abnormal increase in the distance between the eyes (hypertelorism), and a large head (macrocephaly). Individuals have a degree of webbing or fusion (syndactyly), or duplication (polydactyly) of the fingers and toes. Occasionally, those affected may have a short...
(The entire section is 1081 words.)
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