2,3-Diphosphoglycerate Test (Encyclopedia of Medicine)
2,3-diphosphoglycerate (2,3-DPG) is a substance made in the red blood cells. It controls the movement of oxygen from red blood cells to body tissues. 2,3-DPG testing is done to help investigate both a deficiency in red blood cells (anemia) and an unexplained increase of red blood cells, called erythrocytosis.
Hemoglobin, the protein in the blood that carries oxygen, uses 2,3-DPG to control how much oxygen is released once the blood gets out into the tissues. The more 2,3-DPG in the cell, the more oxygen is delivered to body tissues. Conversely, the less 2,3-DPG in the cell, the less oxygen is delivered.
Increasing the amount of 2,3-DPG is the body's primary way of responding to a lack of oxygen. Anemia, obstructive lung disease, cystic fibrosis, and congenital heart disease are all accompanied by increases in 2,3-DPG. When more oxygen is required because of increased metabolism, such as in hyperthyroidism, more 2,3-DPG is produced.
Decreased 2,3-DPG results from an inherited lack of the red blood cell enzymes 2,3-DPG mutase and 2,3-DPG phosphatase. These enzymes are needed to make 2,3-DPG. Without 2,3-DPG to control the movement of oxygen to its tissues, the body responds by making more red blood cells, a condition called erythrocytosis. The outside...
(The entire section is 611 words.)
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