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What explanation does Dr. Manette's letter provide for the actions and vengefulness of Madame Defarge?

Dr. Manette is the attending physician for the Evremonde brother who has mortally wounded the brother of a youthful Madame DeFarge.  As the son of the Evremonde twin, Charles Darnay is called to retribution because Madame Defarge wishes to exterminate the Evremondes just as they destroyed her family.  This lust for vengeance in Mme. DeFarge has stored up its potency through long years of malevolent brooding, just as the revolution in France has been brooding for years.  Thus, the French Revolution and its guillotine are perfect vehicles for her private war against the Evremonde family.