Herniated Disk

Definition

Disk herniation is a rupture of fibrocartilagenous material (annulus fibrosis) that surrounds the intervertebral disk. This rupture involves the release of the disk's center portion containing a gelatinous substance called the nucleus pulposus. Pressure from the vertebrae above and below may cause the nucleus pulposus to be forced outward, placing pressure on a spinal nerve and causing considerable pain and damage to the nerve. This condition most frequently occurs in the lumbar region and is also commonly called herniated nucleus pulposus, prolapsed disk, ruptured intervertebral disk, or slipped disk.

Description

The spinal column is made up of 26 vertebrae that are joined together and permit forward and backward bending, side bending, and rotation of the spine. Five distinct regions comprise the spinal column, including the cervical (neck) region, thoracic (chest) region, lumbar (low back) region, sacral and coccygeal (tailbone) region. The cervical region consists of seven vertebrae, the thoracic region includes 12 vertebrae, and the lumbar region contains five vertebrae. The sacrum is composed of five fused vertebrae, which are connected to four fused vertebrae forming the coccyx. Intervertebral disks lie between each adjacent vertebra.

Each disk is composed of a gelatinous material in the center, called the nucleus pulposus, surrounded by rings of a fibrous tissue (annulus fibrosus). In disk herniation, an intervertebral disk's central portion herniates through the surrounding annulus fibrosus into the spinal canal, putting pressure on a nerve root. (There is often a progression of small fissures in the annulus fibrosis before the disk herniates.) Disk herniation most commonly affects the lumbar region between the fifth lumbar vertebra and the first sacral vertebra. However, disk herniation can also occur in the cervical spine. The incidence of cervical disk herniation is most common between the fifth and sixth cervical vertebrae. The second most common area for cervical disk herniation occurs between the sixth and seventh cervical vertebrae. Disk herniation is less common in the thoracic region.

Predisposing factors associated with disk herniation include age, gender, and work environment. The peak age for occurrence of disk herniation is between 20–45 years of age. Studies have shown that males are more commonly affected than females in lumbar disk herniation by a 3:2 ratio. Genetic factors are suspected of playing a role in disk herniation. Prolonged exposure to a bent-forward work posture is correlated with an increased incidence of disk herniation. Pain from a herniated disk is usually greatest when sitting and is lessened when standing.

There are four classifications of disk pathology:

  • A protrusion may occur where a disk bulges without rupturing the annulus fibrosis.
  • The disk may prolapse where the nucleus pulposus migrates to the outermost fibers of the annulus fibrosis.
  • There may be a disk extrusion, which is the case if the annulus fibrosis perforates and material of the nucleus moves into the epidural space.
  • The sequestrated disk may occur as fragments from the annulus fibrosis and nucleus pulposus are outside the disk proper.

Causes and symptoms

Any direct, forceful, and vertical pressure on the lumbar disks can cause the disk to push its fluid contents into the vertebral body. Herniated nucleus pulposus may occur suddenly from lifting, twisting, or direct injury, or it can occur gradually from degenerative changes with episodes of intensifying symptoms. As individuals age, the intervertebral disk changes in shape and volume. Changes in the chemical and mechanical characteristics of the disk also occur. It is these changes that predispose certain individuals to disk herniation. The annulus may also become weakened over time, allowing stretching or tearing and leading to a disk herniation. Depending on the location of the herniation, the herniated material can also press directly on nerve roots or on the spinal cord, causing a shock-like pain (sciatica) down the legs, weakness, numbness, or problems with bowels, bladder, or sexual function.

Diagnosis

A variety of non-invasive physical tests can be performed to help diagnose disk herniation. A straight-leg raising test may be performed by the health practitioner. If severe pain is produced in the back of the leg, then it may suggest a lumbar nerve root problem. A crossed straight-leg raising test may also be performed. This involves raising the leg opposite to that with current pain. This test tends to produce a more localized but less intense pain than the straight-leg raising test. Several radiographic tests are useful for confirming a diagnosis of disk herniation and locating the source of pain. These tests also help the surgeon indicate the extent of the surgery needed to fully decompress the nerve. X rays show structural changes of the lumbar spine. Myelography is a special x ray of the spine in which a dye or air is injected into the patient's spinal canal. The patient lies strapped to a table as the table tilts in various directions and spot x rays are taken. X rays showing a narrowed dye column in the intervertebral disk area indicate possible disk herniation.

Computed tomography, or computed axial tomography (CT or CAT) scans reveal the details of pathology necessary to obtain consistently good surgical results. Magnetic resonance imaging (MRI) analysis of the disks can accurately detect the early stages of disk aging and degeneration. MRI is most useful in assessing how the disk and nerve roots change over time. The MRI has become the standard diagnostic imaging tool for disk herniation. A newer technology called magnetic resonance myelography does not provide a better overall image of the spine than an MRI, but it can improve diagnosis of disk herniation in some cases.

Treatment

Drugs

Unless serious neurologic symptoms occur, herniated disks can initially be treated with pain medication and up to 48 hours of bed rest. There is no proven benefit from resting more than 48 hours. Many patients benefit from lying on a very firm mattress or an ordinary mattress with a board placed underneath. Heat or cold applied to the affected region often helps many patients. Patients are then encouraged to gradually increase their activity. Pain medications, including non-steroidal anti-inflammatory drugs, muscle relaxers, or in severe cases, narcotics, may be continued if needed.

Epidural steroid injections have been used to decrease pain by injecting an anti-inflammatory drug, usually a corticosteroid, around the nerve root to reduce inflammation and edema (swelling). This partly relieves the pressure on the nerve root as well as resolves the inflammation. Some physicians are using trigger point injections of lidocaine without epinephrine to provide localized pain relief for extended periods of time. Some of these physicians also use electrical or ultrasound therapy over these localized areas, but these methods have not been scientifically validated.

Physical therapy

Physical therapists are skilled in treating acute back pain caused by disk herniation. The physical therapist can provide noninvasive therapies, such as ultrasound or diathermy to project heat deep into the tissues of the back or administer manual therapy, if mobility of the spine is impaired. They may help improve posture and develop an exercise program for recovery and long-term protection. Appropriate exercise can help take pressure off inflamed nerve structures, while improving overall posture and flexibility. Traction can be used to try to decrease pressure on the disk. A lumbar support can be helpful for a herniated disk at this level as a temporary measure to reduce pain and improve posture.

Surgery

Surgery is often appropriate for conditions that do not improve with the usual treatment. In this event, a strong, flexible spine is important for a quick recovery after surgery. There are several surgical approaches to treating a herniated disk, including the classic discectomy, microdiscectomy, or percutaneous discectomy. The basic differences among these procedures are the size of the incision, how the disk is reached surgically, and how much of the disk is removed.

Discectomy is the surgical removal of the portion of the disk that is putting pressure on a nerve causing the back pain. In the classic disectomy, the surgeon first enters through the skin and then removes a bony portion of the vertebra called the lamina, hence the term laminectomy. The surgeon removes the disk material that is pressing on a nerve. Rarely is the entire lamina or disk removed. Often, only one side is removed and the surgical procedure is termed hemilaminectomy.

In microdiscectomy, through the use of an operating microscope, the surgeon removes the offending bone or disk tissue until the nerve is free from compression or stretch. This procedure is possible using local anesthesia. Microsurgery techniques vary and have several advantages over the standard discectomy, such as a smaller incision, less trauma to the musculature and nerves, and easier identification of structures by viewing into the disk space through microscope magnification.

Percutaneous disk excision is performed on an out-patient basis, is less expensive than other surgical procedures, and does not require a general anesthesia. The purpose of percutaneous disk excision is to reduce the volume of the affected disk indirectly by partial removal of the nucleus pulposus, leaving all the structures important to stability practically unaffected. In this procedure, large incisions are avoided by inserting devices that have cutting and suction capability. Suction is applied and the disk is sliced and aspirated.

Athroscopic microdiscectomy is similar to percutaneous discectomy, however it incorporates modified arthroscopic instruments, including scopes and suction devices. A suction irrigation of saline solution is established through two entry sites. A video discoscope is introduced from one site and the deflecting instruments from the opposite side. In this way, the surgeon is able to search and extract the nuclear fragments under direct visualization.

Laser disk decompression is performed using similar means as percutaneous excision and arthroscopic microdiscectomy, however laser energy is used to remove the disk tissue. Here, laser energy is percutaneously introduced through a needle to vaporize a small volume of nucleus pulposus, thereby dropping the pressure of the disk and decompressing the involved neural tissues. One disadvantage of this procedure is the high initial cost of the laser equipment. It is important to realize that only a very small percentage of people with herniated lumbar disks go on to require surgery. Further, surgery should be followed by appropriate rehabilitation to decrease the chance of reinjury.

Chemonucleolysis

Chemonucleolysis is an alternative to surgical excision. Chymopapain, a purified enzyme derived from the papaya plant, is injected percutaneously into the disk space to reduce the size of the herniated disks. It hydrolyses proteins, thereby decreasing water-binding capacity, when injected into the nucleus pulposus inner disk material. The reduction in size of the disk relieves pressure on the nerve root.

Spinal fusion

Spinal fusion is the process by which bone grafts harvested from the iliac crest (thick border of the ilium located on the pelvis) are placed between the intervertebral bodies after the disk material is removed. This approach is used when there is a need to reestablish the normal bony relationship between the vertebrae. A total discectomy may be needed in some cases because lumbar spinal fusion can help prevent recurrent lumbar disk herniation at a particular level.

Alternative treatment

Acupuncture involves the injection of fine needles to relieve pain. An acupuncturist determines the location of the nerves affected by the herniated disk and positions the needles appropriately. Massage therapists may also provide short-term relief from a herniated disk. Following manual examination and x-ray diagnosis, chiropractic treatment usually includes manipulation to correct muscle and joint malfunctions, while care is taken not to place an additional strain on the injured disk. If a full trial of conservative therapy fails, or if neurologic problems (weakness, bowel or bladder problems, and sensory loss) develop, the next step is usually evaluation by an orthopedic surgeon.

Health care team roles

Nurses play an important role in the diagnosis and treatment of disk herniation disease. They assist health care practitioners in performing basic physical testing, such as the straight-leg raising test. They also play an important role in determining the history of the patient and how the patient developed the herniated disk. They also will often assist in procedures such as the steroid or lidocaine injection. Surgical nurses assist in the operative repair of herniated disks.

Physical therapists play an important role in the prevention and treatment of patients with herniated disk disease. They can create an exercise and posture program that can reduce the risk of developing the condition in the


KEY TERMS


Annulus fibrosis—The outer portion of the inter-vertebral disk made primarily of fibrocartilage rings.

Epidural space—The space immediately surrounding the outer most membrane of the spinal cord.

Excision—The process of excising, removing, or amputating.

Fibrocartilage—Cartilage that consists of dense fibers.

Nucleus pulposus—The center portion of the intervertebral disk that is made up of a gelatinous substance.

Percutaneous—Performed through the skin.


first place as well as generate a course of therapy that will help restore function in those with serious disease.

Radiologic technologists play a critical role in the diagnosis of disk herniation. They are involved in the three most important diagnostic imaging tests: CAT scans, MRI procedures, and x rays.

Patient education

Nurses play a critical role in patient education in the prevention and treatment of disk herniation. One of the most important areas in which they educate patients is following disk herniation surgery. These postoperative care instructions are vital to the success of the surgery. Pharmacists play a key role in dispensing accurate information about the proper use of drugs, particularly non-steroidal anti-inflammatory agents, muscle relaxants, and narcotic-based compounds. They also provide instructions to patients on the proper use of drugs pre scribed following surgery. Physical therapists instruct individuals on how to properly lift heavy objects, how to maintain good posture while working and during other activities, and how to perform certain exercises to pre vent or treat disk herniation. Occupational therapists provide information to individuals and employers on how to minimize back and neck strain in the workplace. Dietitians can design a weight-loss program in those cases where extra weight helped precipitate and aggra vate disk herniation.

Prognosis

Only 5–10% of patients with unrelenting sciatica and neurological involvement, leading to chronic pain of the lumbar spine, need to have a surgical procedure performed. This strongly suggests that many patients with herniated disks at the lumbar level respond well to conservative treatment. For those patients who do require surgery for lumbar disk herniation, the reviewed procedures of nerve root decompression caused by disk herniation is favorable. Results of studies varied from 60–90% success rates. Disk surgery has progressively evolved in the direction of decreasing invasiveness. Each surgical procedure is not without possible complications, which can lead to chronic low back pain and restricted lifestyle.

Prevention

Proper exercises to strengthen the lower back and abdominal muscles are key in preventing excess stress and compressive forces on lumbar disks. Good posture will help prevent problems on cervical, thoracic, and lumbar disks. A good flexibility program is critical for prevention of muscle and spasm that can cause an increase in compressive forces on disks at any level. Proper lifting of heavy objects is important for all muscles and levels of the individual disks. Good posture in sitting, standing, and lying down is helpful for the spine. Losing weight, if needed, can prevent weakness and unnecessary stress on the disks caused by obesity. Choosing proper footwear may also be helpful to reduce the impact forces to the lumbar disks while walking on hard surfaces. Wearing special back support devices may be helpful if heavy lifting is required with combinations of twisting.

Resources

BOOKS

Beers, Mark H. et al. The Merck Manual of Diagnosis and Therapy Whitehouse Station, NJ: Merck, 1999.

Current Medical Diagnosis & Treatment 2001. Ed. Lawrence M. Tierney et al. New York: Lange, 2001.

Fauci, Anthony S. Harrison's Principles of Internal Medicine. New York: McGraw-Hill, 1998.

Ferri, Fred F. Ferri's Clinical Advisor. St.Louis: Mosby, 2001.

PERIODICALS

Humphreys, S. Craig et al. "Clinical Evaluation and Treatment Options for Herniated Lumbar Disc." American Family Physician 59 (1999).

McCall, I.W. "Lumbar Herniated Disks." Radiol Clin North Am 38 (200).

Miyamoto H. et al. "The Role of Cyclooxygenase-2 and Inflammatory Cytokines in Pain Induction of Herniated Lumbar intervertebral Disc." Kobe Journal of Medical Science 46 (2000).

Patel, Atul T. et al. "Diagnosis and Management of Acute Low Back Pain." American Family Physician 61 (2000).

Pui M.H. et al. "Value of Magnetic Resonance Myelography in the Diagnosis of Disk Herniation and Spinal Stenosis." Australasia Radiology 44 (2000).

Vanichkachorn, J.S. et al. "Thoracic Disk Disease: Diagnosis and Treatment." Journal of the American Academy of Orthopedic Surgery 8 (2000).

OTHER

FreedomQuest Inc. "Acupuncture." 1998. <http://acupuncture.com/Acup/AcuInd.htm>.

Medical Strategies Inc. (MSI). "Back Pain." 1993-1998. Healthtouch Online. <http://www.healthtouch.com>.

ORGANIZATIONS

American Chronic Pain Association. P.O. Box 850, Rocklin, CA 95677-0850. 1-916-632-0922. <http://www.theacpa.org>.

National Chronic Pain Outreach Association. P.O. Box 274, Millboro, VA 24460. 1-540-862-9437. ncpoa@cfw.com.

Mark Mitchell