At its heart, Mumbo Jumbo is a struggle between the Judeo-Christian Ethic and what Reed calls the Neo-HooDoo Aesthetic. The catalyst for the struggle is a mysterious "anti-plague" called "Jes Grew," a "disease" that forces its "victims" to dance and let their inhibitions go. Since the Neo-HooDoo Faction feels "laughter washes the heart," they are excited and supportive of Jes Grew, whereas the secret society attempting to subdue the plague, the Knights Templar, is aligned with the Wallflower Order. They are intent on stopping Jes Grew before it gets to New York City.
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