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Definition

Fibrinogen (Factor I) is a protein that originates in the liver. It is converted to fibrin during the blood-clotting process (coagulation).

Purpose

The fibrinogen test aids in the diagnosis of suspected clotting or bleeding disorders caused by fibrinogen abnormalities.

Precautions

This test is not recommended for patients with active bleeding, acute infection or illness, or in those patients who have received blood transfusions within four weeks.

Drugs that may increase fibrinogen levels include estrogens and oral contraceptives. Drugs that may cause decreased levels include anabolic steroids, androgens, phenobarbital, urokinase, streptokinase, and valproic acid.

Description

Fibrinogen plays two essential roles in the body: it is a protein called an acute-phase reactant that becomes...