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Is X-linked adrenoleukodystrophy an example of peroxisome?

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lovekblue | Student, Grade 11 | (Level 1) Salutatorian

Posted February 19, 2012 at 11:29 PM via web

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Is X-linked adrenoleukodystrophy an example of peroxisome?

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crmhaske | College Teacher | (Level 3) Associate Educator

Posted February 27, 2012 at 1:52 AM (Answer #1)

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Peroxisomes, which are organelles that are found in nearly all eukaryotic cells, are involved in the breakdown of very long chain fatty acids through beta-oxidation.  X-linked adrenoleukodystrophy is a peroxisomal disorder that affects the human nervous system.  It is a rare, genetic disorder that leads to progressive brain damage, failure of the adrenal glands, and eventually death.  The axons of neurons in the central and peripheral nervous systems are insulated by a fatty tissue called myelin, and it is this myelin sheath that is damaged in adrenoleukodystophy.  When the myelin has been damaged, nerves are unable to aid in the conduction of an impulse.



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