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In Act 2, the only suspicion of Macbeth that arises comes from Macduff. In Scene 4, the very end of Act 2, Rosse, Macduff, and the Old Man discuss the murder of Duncan and the flight of Malcolm and Donalbain. They discuss the fact that the other noblemen suspect the king's sons of foul play because they have fled Scotland and now look guilty; however, Macduff does not agree. When asked whether he will go to Scone to see Macbeth's coronation, Macduff replies that he will not go and will instead return to his home in Fife. This is an outright act of defiance on the part of Macduff who as a nobleman would likely be expected to attend the ceremony. So, Macduff's actions suggest that he does not trust Macbeth.
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