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You may receive a range of different responses to this question based on personal opinion. For me, what swings it is the appearance of the ghost of Caesar before the end of Act IV to Brutus, and the impact it has had on him. By this stage of course it is clear that the alliance between the conspirators is beginning to crack up, as signified by the way that Cassius and Brutus are fighting and quarrelling. Also, more importantly, Brutus is beginning to doubt the wisdom of assassinating Caesar and he has lost his beloved wife. The appearance of the Ghost cements his feeling of unease and fear at what has happened and what is to come. Note what he says in response to the appearance of the Ghost:
I think it is the weakness of mine eyes
That hsapes this monstrous apparition.
It comes upon me. Art thou anything?
Art thou some god, some angel, or some devil,
That mak'st my blood cold, and my hair to stare?
Brutus is clearly the tragic hero of this Act, and the way he is subjected to the Ghost indicates the depth of his psychological trauma.
Brutus is the obviously answer and the last poster gave an excellent explanation of why. I also feel bad for Lepidus. He is part of the new triumvirate along with Antony and Octavius. He seems to be a team player, yet Antony has no respect for him. He tells Octavius of his plans to get rid of Lepidus as soon as the war is over. Octavius disagrees but doesn't try too hard to take a stand against Lepidus. It shows Antony is every bit as ambitious as Caesar and Lepidus will likely fall victim to Antony just like Pompei did to Caesar.
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